Test your oncology knowledge with JAMA Network clinical challenges

Earning CME credits online has never been quicker or easier.

JN Learning™, the CME arm of the JAMA Network™, enables users to browse the JAMA Network catalogue of over 5,000 online resources by any medical topic. A filter then lets users locate more than 1,700 relevant online CME opportunities.

CME from the JAMA Network also enables you to earn AMA PRA Category 1 CME Credit™ from a source you trust. The AMA has added lessons for many of the most common specialty health topics.

The oncology category helps learners correctly diagnose and treat unusual presentations of acute myeloid leukemia, skin and Burkitt lymphoma, lung cancer and more. Its 10-lesson online series covers the following topics:

1. “Painful Eruptions in a Patient With Cholangiocarcinoma Treated With Fibroblast Growth Factor Receptor Inhibitor.”

   1. A 65-year-old woman with locally advanced, unresectable intrahepatic cholangiocarcinoma being treated with pemigatinib, a fibroblast growth factor receptor inhibitor (FGFRi), presented with a painful eruption on the bilateral lower extremities. What is your diagnosis?

2. “Asymptomatic Purpuric Eruption on the Scalp of a Middle-Aged Man.”

   1. A man in his 60s presented to the clinic with a several-day history of nontender, nonitchy purpuric rash on his scalp. The patient denied using any over-the-counter or prescription topicals at the affected sites before the onset of the eruption except for petroleum jelly. What would you do next?

3. “Typical Kidney Tumor With Atypical Presentation.”

   1. A woman in her late 50s with a medical history of osteoporosis, hyperlipidemia and migraines presented with hematuria. Results of computed tomography imaging showed an 8 cm by 6 cm by 5 cm right kidney lesion. What is your diagnosis?

4. “Scalp Eruption in a Patient With Metastatic Colon Cancer.”

   1. A 73-year-old man with metastatic BRAF-mutant colorectal cancer presented with a one-month history of crusted lesions with purulent drainage on the scalp, with associated pruritus and pain. Five months earlier, he began treatment with cetuximab, binimetinib and encorafenib, complicated by a grade 1 acneiform eruption that was managed with doxycycline hyclate and topical hydrocortisone and clindamycin phosphate. What is your diagnosis?

5. “Anuric Kidney Failure in a Patient With Metastatic Melanoma.”

   1. A 53-year-old man received a diagnosis of stage 4 melanoma with metastatic disease to the spine and brain three months before presentation. Four weeks following receipt of immunotherapy with ipilimumab and nivolumab, he developed acute abdominal pain in the setting of a rapidly rising lactic acid dehydrogenase levels, prompting hospital admission. What is your diagnosis?

6. “Generalized Asymptomatic Skin Nodules in a Young Man.”

   1. A 29-year-old man presented with a two-month history of rapidly growing, widespread, asymptomatic skin nodules all over his body. He denied having fever, chills, fatigue, night sweats or weight loss. He had no history of malignant neoplasm or chemical exposure. What would you do next?

7. “Red Plaques in a Pediatric Patient With Acute Leukemia of Ambiguous Lineage.”

   1. A 16-year-old boy with acute leukemia of ambiguous lineage developed tender, 1–2 cm erythematous plaques and nodules during treatment with chemotherapy. Previously, he had been well, with morphological remission found on a recent bone marrow biopsy. What is your diagnosis?

8. “Painful Cutaneous Plaques on the Lower Legs in a Middle-Aged Woman.”

   1. A 47-year-old woman presented with a seven-month history of multiple painful erythematous plaques on her lower legs. The lesions appeared as erythematous nodules on the left leg with tenderness and pruritus and rapidly progressed to both legs. What is your diagnosis?

9. “Progressive Dyspnea in a Woman With Genital Skin Lesions.”

   1. An 82-year-old woman presented with dyspnea on exertion and weight gain of 5 kg over the past month. Her medical history included atrial fibrillation and lung adenocarcinoma—a lung lobectomy was performed eight years ago. What is your diagnosis?

10. “Erythematous Patch With Central Papules on the Forehead of a Middle-Aged Woman.”

    1. A 55-year old woman presented with a six-week history of an enlarging, tender, pruritic, 4 cm erythematous patch with central inflammatory papules distributed on the medial forehead. No inciting events, such as arthropod bite or trauma, were noted. What would you do next?

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